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Impurity of Loperamide Hydrochloride API
Loperamide EP Impurity F / Loperamide USP Related Compound F
Impurity
GS.42.LOP.06_1791015162.png
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Product Name Loperamide EP Impurity F / Loperamide USP Related Compound F
Product Category Impurities, Intermediates
Sub-Category Metabolites, Heterocycles, Pharmaceutical Standards, drug analogues
CAS No 106900-12-3
Catalog Number GS.42.LOP.06
Chemical Name/Synonyms trans-Loperamide N-Oxide ; 4-[trans-4-(4-Chlorophenyl)-4-hydroxy-1-oxidopiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide ; trans-4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide 1-Oxide
Molecular Weight 493.04
Molecular Formula C29H33ClN2O3
Purity NLT 95%
Solubility Alcohol, Methylene Chloride.
Applications Loperamide oxide is a prodrug of Loperamide. It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperamide in jejunum and colon.
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